A strange time this may seem to some of you, my brethren, and a strange place, to commence an enterprise such as that, which relying on God’s mercy, we are undertaking this day. In this huge city, amid a population of human beings, so vast that each is solitary, so various that each is independent, which, like the ocean, yields before and closes over every attempt made to influence and impress it,-in this mere aggregate of individuals, which admits of neither change nor reform, because it has no internal order, or disposition of parts, or mutual dependence, because it has nothing to change from and nothing to change to, where no one knows his next-door neighbour, where in every place are found a thousand worlds, each pursuing its own functions unimpeded by the rest-how can we, how can a handful of men, do any service worthy of the Lord who has called us, and the objects to which our lives are dedicated?